Objective
The project is aimed at the biochemical and biological investigation of a new class of molecules with azinic core (triazine, pyrimidine, etc.), featuring (1) detergent properties, for the transfer of oligonucleotidic genetic material (DNA, RNA, and mimics like PNA, etc.) into the cell nucleus (transfection), and (2) low cytotoxicity. The other principal structural features are: a thiol moiety for the formation of disulfide bridges in aqueous DNA and RNA, solutions; a protonable amine function not linked to the azinic core; a lipophilic chain to provide lipidic characteristics.These molecules could be used as transfection reagents for biological, biochemical and biomedicinal laboratories, and in perspective as drugs for gene therapy.The work will be carried o ut within the frame of a collaboration between the host Institution (CNR-ICRM) and Politecnico di Milano, which in turn hosts the CNR-ICRM section, in a new biology laboratory (Bio Cell) recently set up for the study of biological applications of engineeri ng and chemistry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences biological sciences genetics RNA
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ROME
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.