Objective
Even though melanoma is the less frequent skin cancer, it is very likely to metastasise and lead to fatal consequences. It is worth it to take into consideration that, during the pass thirty years its incidence has increased significantly and that it has a very poor response to the currently available therapies. Different mouse models has been used to describe cutaneous melanoma, however, these tumours do not have the epidermal component that characterize the conventional human melanomas. Here, we use an ultra violet (UV) radiation, an environmental insult that has been epidemiologically related to the melanoma acquisition, to induced melanoma development in HGF transgenic mice.
The melanoma tumours raised in the HGF transgenic mice resembles human cutaneous melanoma with respect the aetiology, histopathology and molecular pathogenesis. Receptor tyrosine kinases (RTK) and human cancer are very closed related. Aberrant c-MET signalling (HGF receptor) has been implicated in the development and progression of a wide variety of human cancers, including melanoma. CDKN2A is the only tumour suppressor locus that has been unambiguously identified as a melanoma susceptibility gene. We also know from mouse models that Ras pathway activation is very important in melanoma development. However, the analysis of all the data suggest that the contribution of the HGF signalling in this mouse melanoma model can not be explained just with the Ras pathway activation.
The specific contributions made by the HGF signalling in these melanoma model that make this animal model so unique, are unknown. Briefly the objectives for the project are: (i) Isolation, purification and identification of differentially modified phopho-proteins in response to HGF in melanoma, (ii) Relevance and validation in the mouse melanoma model of the candidate or candidates chosen in the first part of the project in the tumour's development and progression, (iii) Correlation of the obtained data with human melanoma.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering
- medical and health sciences clinical medicine oncology skin cancer melanoma
- natural sciences biological sciences biochemistry biomolecules proteins
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.