Objective
The objective of this proposal is to define the role of histone deacetylase 4 (HDAC4) and myocyte enhancer factor 2 (MEF2) in muscle regeneration and dystrophy. In response to injury, skeletal muscle activates orchestrated molecular mechanisms to restore muscle architecture and functionality. Our preliminary data showed that skeletal muscle from mice lacking HDAC4, an inhibitor of the myogenic factor MEF2, regenerates better than that of control mice following injury. MEF2 activity is triggered in healthy myofibers surrounding the injured area, suggesting a potential role of MEF2 in paracrine regulation of adult muscle regeneration. We demonstrated that MEF2 controls the expression of caveolin3, an inhibitor of myostatin, a negative regulator of muscle mass. In this proposal, we plan to define the role of HDAC4 in muscle regeneration by identifying the targets responsible for the improved regeneration observed in HDAC4 null mice. We intend to study how HDAC4 regulates satellite cell proliferation and differentiation. In order to identify secreted factors that may contribute to the improved regeneration in HDAC4 null mice, we plan to perform a proteomic analysis on secretomes from HDAC4 null and control myofibers. Muscular dystrophies are a hereditary myopathies characterized by progressive muscle degeneration and weakness. Promoting muscle repair has been shown to be therapeutically beneficial for muscular dystrophy. We intend to study the role of HDAC4 in muscular dystrophy by characterizing mdx mice lacking HDAC4 in skeletal muscle. We will define MEF2 activity and we will determine target genes controlled by HDAC4 in muscular dystrophy. By delineating the role of HDAC4 in skeletal muscle regeneration and dystrophy, we will provide an experimental framework for developing new drugs to improve muscle repair and ameliorate muscular dystrophy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
00185 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.