Objective
Cardiovascular disease currently is the primary cause of death of two million people in Europe each year. Early cardiovascular disease can be treated effectively and at ever-lower costs. This has raised hopes that if large groups of individuals who are at an increased risk could be identified earlier, morbidity and mortality from the disease could potentially be reduced. New risk questionnaires, biomarkers and computed tomography imaging technology (CT) have identified undiagnosed increased risks in asymptomatic people. However, it is unknown whether such screening for subclinical disease improves outcomes enough to justify the associated adverse effects and costs of the new strategies.
Benefits are only to be expected if large groups of asymptomatic people can be reached. Moreover, evidence can only be shown unambiguously in randomised controlled trials (RCTs). We therefore propose a large-scale population-based screening trial, in which we will invite 330,800 men and women (from population-based registries) to measure their waist circumference and fill out a risk questionnaire. 39,000 persons at elevated risk will then be randomised to either: a) no testing, b) be screened using the classic tests (lipids, glucose, blood pressure) or c) be screened using a CT scan of the coronary arteries. The first objective of the trial is to establish whether inviting (and subsequently selecting high-risk) asymptomatic men and women for a ‘classic’ risk factor assessment, followed by early and intensive medical intervention in subjects at increased risk, will decrease coronary heart disease (CHD) mortality and morbidity by 15% or more within five years. The second objective is to establish whether the coronary calcium score using CT will improve outcomes with another 15% for asymptomatic persons. The third objective is to model the natural history of atherosclerotic plaques and CHD risk, to estimate effects, adverse effects and costs, and to guide public health policies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- social sciences sociology demography mortality
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine cardiology cardiovascular diseases
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-ADG_20110310
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
3015 GD Rotterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.