Objective
The main goal of this proposal is to understand the epigenetic mechanisms involved in the establishment and propagation of active chromatin states of genes during embryonic and postnatal liver development. The proposal is focused on a novel concept, put forward by the host group's previous studies, which suggest the generation of a poised, or committed state of active chromatin early during hepatocyte differentiation.
The research plan includes genome-wide gene expression analysis and biochemical approaches for chromatin structure and function studies in conjunction with DNA and RNA fluorescence in situ hybridization (FISH) assays. Besides wild type animals we also plan to study specific KO mice. While the host group has strong expertise in chromatin analysis using biochemical approaches it lacks the required experience in embryology, gene disruption and molecular imaging technologies. We seek to gain these latter expertise through the transfer of knowledge from recruited experienced researchers.
The host group will provide state of the art facilities and training in the field of gene expression and chromatin research. The project is expected to provide new insights into the poorly understood mechanisms involved in epigenetic regulation of active chromatin states. It will also have a great impact to the host in terms of enhanced competitiveness in the field of epigenetic research, technological competence and increased cohesion with European research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1527 HERAKLION
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.