Objective During my ERC starting grant project, my lab has identified small molecule inhibitors that inhibit the proliferation of MYB-dependent leukemia cell lines. In this proof of concept project, we aim to investigate the potential of these compounds to be further developed as anti-cancer agents. We will determine their potential to inhibit the proliferation breast cancer and colon cancer cell lines and possible additional activity against other solid tumors. In addition, we will investigate the IP landscape and possibilities to improve the chemical properties. These pre-clinical data should provide the basis for the further development of these MYB inhibitors as anti-cancer agents. Fields of science medical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesclinical medicineoncologycolorectal cancermedical and health sciencesclinical medicineoncologyleukemia Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-OA-2011-PoC - European Research Council ERC Proof of Concept Call for proposal ERC-2011-PoC See other projects for this call Funding Scheme CSA-SA(POC) - Supporting action (Proof of Concept) Coordinator VIB VZW Address Rijvisschestraat 120 9052 Zwijnaarde - gent Belgium See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Administrative Contact Rik Audenaert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all VIB VZW Belgium EU contribution € 139 100,00 Address Rijvisschestraat 120 9052 Zwijnaarde - gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Administrative Contact Rik Audenaert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
