Objective
Cell migration is a key step for the development of inflammatory and metastatic disease. Mechanisms involved in cell migration include alterations in adhesion molecules and chemokine receptor status, activation of signalling molecules and cytoskeletal rearrangement. Cell-based high content screening (HCS) is a revolutionary technology which allows subcellular imaging of temporary cellular events as well as analysis of intracellular events, permitting the study of deeper biological information at the sub-cellular level.
Hence, due to its high throughput capacity, this technology is likely to improve the bottlenecks in the process leading towards drug discovery, and the establishment of this technological platform in Europe will have immediate applications to many of the causes of morbidity and mortality within the European Union. The laboratory of Prof. Dermot Kelleher, the coordinator of this proposal, is one of the first academic institutions in Europe to acquire such a technology. In this application we propose to combine the efficiency of inhibitory small inhibitory RNA (siRNA) libraries with the high throughput capacity of cell-based HCS to the study of cell migration in the context of neoplastic diseases and inflammation.
This project requests research fellows with expertise in the areas of cell biology/cell migration combined with HCS, IT/bioinformatics, molecular biologists with experience of inhibitory RNA and high throughput transfection technologies and cell biologists with industrial/drug screening experience. This transfer of knowledge to the host institution using siRNA in combination with HCS to study the molecular mechanisms of cell migration will be essential to help establish and develop this novel technology and its use to accelerate the process of drug discovery.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences cell biology
- natural sciences physical sciences optics microscopy
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-3
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.