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Content archived on 2024-06-18

Metamodelling of dynamic models of the heart

Objective

Mathematical modelling of biological systems facilitates a deeper understanding of organ function and disease mechanisms. However, biophysically based models have a complex structure, are computationally demanding and extremely difficult to validate, and comparison of competing models is very challenging. These characteristics seriously delay progress in the use of modelling in sciences such as systems biology and medicine, and as the application of models to both large basic science data sets and in clinical context progresses these issues will become increasingly important. The aim of the proposed project is to reduce these bottlenecks using metamodelling, i.e. generation of statistical approximations of model input-output mappings. The objectives are to 1) reduce computational demand of multi-scale spatiotemporal heart models by substitution of parts of the models with statistical approximations, 2) establish a robust platform for global high-dimensional sensitivity analysis (analysis of the impact of the various input parameters on the model outputs) based on metamodels, enabling more efficient model validation, and 3) develop metamodel-based methodology for model construction and validation through systematic comparison and assessment of the prediction spaces of different models and comparison of models to experimental data. We will build a flexible metamodelling framework based on multivariate regression, adapted to handling the high parameter- and state space- dimensionality characterising multi-scale models. The fellowship will have a large impact on integration of metamodelling into the modelling community due to the central role that the host group has in e.g. the FP7-funded Virtual Physiological Human project. The methodology will be generic and highly instrumental in the development and testing of complex models, and has the potential to make a major impact not only within the modelling community but also across both experimental and clinical sciences.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2011-IEF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

KING'S COLLEGE LONDON
EU contribution
€ 104 516,70
Address
STRAND
WC2R 2LS London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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