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Content archived on 2024-06-18

A High-Throughput Approach for Chemical Reactivity Profiling and Physical Organic Chemistry

Objective

This research proposal challenges current philosophy in reaction analysis in that it offers a HT approach to the generation of reaction
parameters orders of magnitude faster than those currently used; although offering data that is as accurate and as robust (if not more so)
than traditional methods. The aims of this proposal are to initially undertake a systematic and quantitative evaluation of a simple test cases
involving relative amino acid coupling rates before extending studies into the area of nucleophilicity in association with solvent effects but with analysis in an entirely self-consistent and self-correcting manner, Subsequently, the studies would be extended to an
analysis of Buchwald-Hartwig based chemistries and a series of phenols and anilines with the focus on Hammett based analysis of coupling partners. Such an approach will have many practical applications. Thus it will allow the chemistry/activity of new monomers to be determined before application in library synthesis, besides offering an understanding of the suitability of existing monomers in library based SNAr chemistries, and the global analysis of coupling reagents with all amino acid coupling partners.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2011-IEF
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

THE UNIVERSITY OF EDINBURGH
EU contribution
€ 209 033,40
Address
OLD COLLEGE, SOUTH BRIDGE
EH8 9YL Edinburgh
United Kingdom

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Region
Scotland Eastern Scotland Edinburgh
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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