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A High-Throughput Approach for Chemical Reactivity Profiling and Physical Organic Chemistry

Objectif

This research proposal challenges current philosophy in reaction analysis in that it offers a HT approach to the generation of reaction
parameters orders of magnitude faster than those currently used; although offering data that is as accurate and as robust (if not more so)
than traditional methods. The aims of this proposal are to initially undertake a systematic and quantitative evaluation of a simple test cases
involving relative amino acid coupling rates before extending studies into the area of nucleophilicity in association with solvent effects but with analysis in an entirely self-consistent and self-correcting manner, Subsequently, the studies would be extended to an
analysis of Buchwald-Hartwig based chemistries and a series of phenols and anilines with the focus on Hammett based analysis of coupling partners. Such an approach will have many practical applications. Thus it will allow the chemistry/activity of new monomers to be determined before application in library synthesis, besides offering an understanding of the suitability of existing monomers in library based SNAr chemistries, and the global analysis of coupling reagents with all amino acid coupling partners.

Champ scientifique (EuroSciVoc)

Programme(s)

Thème(s)

Appel à propositions

FP7-PEOPLE-2011-IEF
Voir d’autres projets de cet appel

Régime de financement

MC-IEF - Intra-European Fellowships (IEF)

Coordinateur

THE UNIVERSITY OF EDINBURGH
Contribution de l’UE
€ 209 033,40
Adresse
OLD COLLEGE, SOUTH BRIDGE
EH8 9YL Edinburgh
Royaume-Uni
Région
Scotland Eastern Scotland Edinburgh
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
Aucune donnée