Objective
Major changes in carbohydrate expression occur during the onset and progression of cancer. These alterations in glycosylation may result in both the loss of normal carbohydrate antigens (e.g. ABO blood group antigens) and/or high expression of carbohydrate structures that normally have low or restricted expression in healthy adults.
The Tn antigen is expressed in most carcinomas, during embryogenesis, on pathogenic parasites, and on HIV, yet its expression is rare in normal adult tissue, creating a considerable interest in monitoring the expression of the Tn antigen for diagnostic purposes as well as for the development of Tn-based vaccines for cancer and HIV. The accurate detection of the Tn antigen is essential for both basic and applied research. However, monitoring the expression of this antigen is not trivial. Selective recognition of carbohydrate epitopes is challenging, especially for small epitopes such as the Tn antigen, and presently, there is no method nor approach providing an accurate and reliable information on the expression of this antigen.
The goal of present proposal is to “evolve” the GafD lectin as a molecular probe to be used in the detection the Tn tumor biomarker and solve the problem of its recurrent inaccurate detection in cancer. Phage display technology will be used to modulate the properties of GafD throughout rounds of selection against different antigens, accumulating and refining its improvements in selectivity/affinity towards a finely tuned and specific Tn antigen binder. Subsequently, the identified receptor(s) will be expressed and fully characterized by an integrated multidisciplinary approach compressed of glycan microarrays, NMR; ITC; SPR and X-ray crystallography.
The presented research will create a defined, precise and reliable tool for the evaluation of Tn expression, which will have great implications in the development of Tn-based diagnostics and vaccines.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IOF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.