Objective
Until recently, lipids were considered inert compounds that provide permeability barriers between interior and exterior compartments of cells. It is now recognized they are potent regulators of cell functions, including signaling and gene and protein expression. However, the mechanisms remain unclear. Such knowledge is critical since membrane lipid abnormality has been implicated in type 2 diabetes, high blood pressure and cardiovascular disease.
Our strategic aim is to establish a Centre of Excellence in Membrane Lipid Research for Europe by integrating knowledge of membrane lipids, genomic and proteomics. It will be realized by enhancing the research capability of a critical mass of multi-disciplinary researchers of the host institute by recruiting high calibre and experienced researchers and secondments of staff to the institutes of our two partners, which have a complementary research expertise.
To effect optimal transfer of knowledge, the researchers will be embedded in to the collaborative research projects designed to:
- Define membrane lipid map of blood cells of populations with a high intake of omega-6, omega-3 or saturated fatty acids to unravel the link between diets, membrane lipid and disease patterns;
- Map blood cell membrane lipid of pregnant women with gestational diabetes and pregnancy-induced high blood pressure to examine a relationship between membrane lipid composition and the development of the diseases;
- Elucidate the effect of dietary fat on membrane lipid map, signaling and gene and protein expression in cell culture and animal models of chronic diseases;
- Understand the interaction between membrane lipids and amphiphilic psychotropic drugs.
The added values will be
- long-term link between the institution, and the researchers;
- reduction of brain drain of European researchers;
- the establishment of lipidomics as novel discipline that provides a fresh insight into the cause of common chronic diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- medical and health sciencesclinical medicineendocrinologydiabetes
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
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Keywords
Call for proposal
FP6-2004-MOBILITY-3
See other projects for this call
Funding Scheme
TOK - Marie Curie actions-Transfer of KnowledgeCoordinator
LONDON
United Kingdom