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Contenido archivado el 2024-05-29

Lipidomics in human development, health and chronic diseases

Objetivo

Until recently, lipids were considered inert compounds that provide permeability barriers between interior and exterior compartments of cells. It is now recognized they are potent regulators of cell functions, including signaling and gene and protein expression. However, the mechanisms remain unclear. Such knowledge is critical since membrane lipid abnormality has been implicated in type 2 diabetes, high blood pressure and cardiovascular disease.

Our strategic aim is to establish a Centre of Excellence in Membrane Lipid Research for Europe by integrating knowledge of membrane lipids, genomic and proteomics. It will be realized by enhancing the research capability of a critical mass of multi-disciplinary researchers of the host institute by recruiting high calibre and experienced researchers and secondments of staff to the institutes of our two partners, which have a complementary research expertise.

To effect optimal transfer of knowledge, the researchers will be embedded in to the collaborative research projects designed to:
- Define membrane lipid map of blood cells of populations with a high intake of omega-6, omega-3 or saturated fatty acids to unravel the link between diets, membrane lipid and disease patterns;
- Map blood cell membrane lipid of pregnant women with gestational diabetes and pregnancy-induced high blood pressure to examine a relationship between membrane lipid composition and the development of the diseases;
- Elucidate the effect of dietary fat on membrane lipid map, signaling and gene and protein expression in cell culture and animal models of chronic diseases;
- Understand the interaction between membrane lipids and amphiphilic psychotropic drugs.

The added values will be
- long-term link between the institution, and the researchers;
- reduction of brain drain of European researchers;
- the establishment of lipidomics as novel discipline that provides a fresh insight into the cause of common chronic diseases.

Ámbito científico (EuroSciVoc)

Palabras clave

Tema(s)

Convocatoria de propuestas

FP6-2004-MOBILITY-3
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Régimen de financiación

TOK - Marie Curie actions-Transfer of Knowledge

Coordinador

LONDON METROPOLITAN UNIVERSITY
Aportación de la UE
Sin datos
Coste total
Sin datos

Participantes (2)