Objective
Neurodegenerative diseases (NDs) are the neurological disorders which will affect a significantly growing number of people in the context of the aging of the EU's population and worldwide. NDs thus constitute a priority for action. Alzheimer’s Disease (AD) is the most common form of dementia and ND, and a major social and health problem. Preliminary data from the host laboratory identified a subset of significantly deregulated genes in brain tissue of AD affected individuals. We here propose to test how and to which extent activation or suppression of these genes confers susceptibility to AD. We propose two approaches: the first in vitro, to analyze how the modification of the expression of these genes influences neuronal cultures survival and plasticity in the old stage, and the susceptibility of neurons to Amyloid beta toxicity. Then, the most promising genes will be further selected for an in vivo screening in transgenic mouse model of AD, to elucidate whether the alteration of the expression of these genes may modify and hopefully counteract the signs of AD in vivo.
Additionally, as recent advances in Prion diseases, another family of NDs affecting humans and animals, and AD research suggest that AD and Prion diseases converge in many pathogenic aspects, and may even be amenable to similar therapeutic principles, we propose to analyze the contribution of these genes also in Prion disease cellular models, and whether alteration of Prion biology may in turn contribute to AD pathology.
This fellowship will give important information on aberrant genetic, cellular and molecular mechanisms responsible for NDs such as AD, and will open direct leads for early diagnosis and prevention.
The fellow will acquire a more complete and diversified scientific knowledge and technical preparation through a multi-disciplinary approach, and will be trained to become an expert researcher towards an independent research career in the field of neuroscience, in particular of NDs and AD
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.