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Sumoylation: a regulatory mechanism for circadian clock function

Objective

"The past decade has seen a remarkable advance in our understanding of the plant circadian system, mostly in Arabidopsis thaliana. It is now well established that Arabidopsis clock genes and their protein products operate via negative feedback loops that promote rhythmic oscillations in cellular, metabolic and physiologic activities. Evidence about the relevant role of transcriptional mechanisms regulating the circadian clock has been provided in a number of different studies. However, the importance of post-translational regulation within the plant circadian clock still remains to be fully elucidated. In this proposal, we attempt to explore the molecular, cellular and biochemical determinants involved in the post-translational regulation of the Arabidopsis circadian clock. We will characterize protein sumoylation and its regulation of the circadian system, deciphering its potential role modulating the light input to the clock. To date, no other studies have demonstrated the importance of this post-translational modification within the plant circadian field, which provide evidence about the novelty and biological relevance of this proposal. Overall, the successful completion of the proposed objectives will provide a substantial advance on our knowledge of circadian clock function in plants."

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins

Call for proposal

FP7-PEOPLE-2011-IEF
See other projects for this call

Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)
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Coordinator

CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB
Address
Parc De Recerca De L Uab Campus Uab Edifici Crag Bellaterra
08193 Cerdanyola Del Valles
Spain
Activity type
Other
EU contribution
€ 226 548,40
Administrative Contact
Lali Sanz (Ms.)