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Sumoylation: a regulatory mechanism for circadian clock function

Objectif

"The past decade has seen a remarkable advance in our understanding of the plant circadian system, mostly in Arabidopsis thaliana. It is now well established that Arabidopsis clock genes and their protein products operate via negative feedback loops that promote rhythmic oscillations in cellular, metabolic and physiologic activities. Evidence about the relevant role of transcriptional mechanisms regulating the circadian clock has been provided in a number of different studies. However, the importance of post-translational regulation within the plant circadian clock still remains to be fully elucidated. In this proposal, we attempt to explore the molecular, cellular and biochemical determinants involved in the post-translational regulation of the Arabidopsis circadian clock. We will characterize protein sumoylation and its regulation of the circadian system, deciphering its potential role modulating the light input to the clock. To date, no other studies have demonstrated the importance of this post-translational modification within the plant circadian field, which provide evidence about the novelty and biological relevance of this proposal. Overall, the successful completion of the proposed objectives will provide a substantial advance on our knowledge of circadian clock function in plants."

Champ scientifique (EuroSciVoc)

Programme(s)

Thème(s)

Appel à propositions

FP7-PEOPLE-2011-IEF
Voir d’autres projets de cet appel

Régime de financement

MC-IEF - Intra-European Fellowships (IEF)

Coordinateur

CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB
Contribution de l’UE
€ 226 548,40
Adresse
PARC DE RECERCA DE L UAB CAMPUS UAB EDIFICI CRAG BELLATERRA
08193 CERDANYOLA DEL VALLES
Espagne
Région
Comunidad de Madrid Comunidad de Madrid Madrid
Type d’activité
Other
Liens
Coût total
Aucune donnée