Objective
Mitochondria play an essential role in controlling normal cellular bioenergetics, however, the mitochondrial theory of ageing suggests that these organelles may be detrimental due to excessive production of reactive oxygen species. In addition, under certain conditions, mitochondria control the process of cell death by releasing pro-apoptotic proteins into the cytosol.
A large collection of proteins in mitochondria contribute to the normal/abnormal functioning of these organelles which in turn has important implications for a number of human diseases such as age-related diseases such as Parkinson's disease, Alzheimer's disease and cancer. A number of functional differences are known to be present in mitochondria from different organ/tissue sources, however, until now no one has performed a comprehensive proteomics analysis of mitochondria from different brain regions and different neuronal localisations.
In the Department of Biochemistry, Trinity College Dublin, there already exists a nucleus of mitochondrial and neurodegenerative researchers as well as recently established proteomics and imaging facilities. However, experienced researchers with expertise in all of these areas are lacking, therefore, this proposal describes a plan to transfer knowledge from experts in the proteomics field to experts in the mitochondria field in Trinity College Dublin. In return, the Marie Curie Research fellows will receive intensive training in the area of bioenergetics and neurodegenerative diseases.
An immediate outcome will be the generation of important information concerning the nature of mitochondrial proteins and their relationship to ageing and age-related diseases. Finally, the establishment of a ToK network will allow for transfer of knowledge from European centers of excellence as well as new research collaboration with an associated candidate state, Turkey.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences basic medicine neurology neurodegenerative diseases dementia alzheimer
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine neurology neurodegenerative diseases parkinson
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.