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Characterisation of mitochondrial proteins in brain

Ziel

Mitochondria play an essential role in controlling normal cellular bioenergetics, however, the mitochondrial theory of ageing suggests that these organelles may be detrimental due to excessive production of reactive oxygen species. In addition, under certain conditions, mitochondria control the process of cell death by releasing pro-apoptotic proteins into the cytosol.

A large collection of proteins in mitochondria contribute to the normal/abnormal functioning of these organelles which in turn has important implications for a number of human diseases such as age-related diseases such as Parkinson's disease, Alzheimer's disease and cancer. A number of functional differences are known to be present in mitochondria from different organ/tissue sources, however, until now no one has performed a comprehensive proteomics analysis of mitochondria from different brain regions and different neuronal localisations.

In the Department of Biochemistry, Trinity College Dublin, there already exists a nucleus of mitochondrial and neurodegenerative researchers as well as recently established proteomics and imaging facilities. However, experienced researchers with expertise in all of these areas are lacking, therefore, this proposal describes a plan to transfer knowledge from experts in the proteomics field to experts in the mitochondria field in Trinity College Dublin. In return, the Marie Curie Research fellows will receive intensive training in the area of bioenergetics and neurodegenerative diseases.

An immediate outcome will be the generation of important information concerning the nature of mitochondrial proteins and their relationship to ageing and age-related diseases. Finally, the establishment of a ToK network will allow for transfer of knowledge from European centers of excellence as well as new research collaboration with an associated candidate state, Turkey.

Wissenschaftliches Gebiet (EuroSciVoc)

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Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-3
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

TOK - Marie Curie actions-Transfer of Knowledge

Koordinator

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (HERINAFTER CALLED T.C.D.)
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