Objective
"To address the current gap in the literature in defining a suitable synthetic route toward the pharmaceutically and structurally unique cytotoxic natural products, the daphniyunnines, we wish to develop the requisite methods and strategies during this fellowship. Using novel, synthetically flexible and powerful, enantioselective organocatalytic cascade reactions will facilitate our goals in this project. Specifically, we propose to develop an novel, asymmetric organocatalyst-controlled cascade Michael-Horner-Wadsworth-Emmons reaction and a subsequent gold(I)-catalysed hydroalkylation. This would establish a novel, powerful and broadly applicable organocatalytic asymmetric strategy toward this moiety. The second objective is to address our ability to access the complex natural products via a common divergent intermediate. To accomplish this, a cascade Michael-aldol condensation reaction will yield a common advanced tetracyclic intermediate which be further elaborated toward the daphniyunnine natural products and additional analogues. This will secure sufficient quantities to fully determine the therapeutic potential of these molecules. This will enable rapid entrance toward structurally intricate intermediates and would ultimately have a profound impact in the understanding of the power of organocatalytic cascade methods in organic synthesis."
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.