Objective
"Epidemiological studies have clearly demonstrated that obesity and Type 2 diabetes are associated with an increased risk of developing common cancers including breast and colon cancer. They are also associated with increased cancer related mortality. While the mechanisms involved in this association are not yet defined, insulin resistance, hyperinsulinemia, hyperlipidemia, hyperglycemia and inflammatory cytokines are thought to be involved.
Our studies, using separate mouse models of obesity or Type 2 diabetes, have replicated the increased association of these conditions and breast cancer. We have shown that endogenous hyperinsulinemia maybe an important contributing factor in the increased cancer risk. We propose to extend these studies in a number of directions. Firstly to confirm the findings using a mouse colon cancer cell lines. We will also study metastases, using a specific breast cancer cell line that spreads to the lungs and colon cancer that spreads to the liver. In these mouse experiments we will use specific blockers to the insulin and IGF-1 receptors to determine if the role of endogenous hyperinsulinemia is indeed a major factor in metastases and through which receptor it propagates a signaling cascade. Studies on the molecular mechanisms will be carried out on cells in culture and in the tissue samples from the tumors and metastases from lung and liver.
We have also developed a model of hyperlipidemia and cancer and preliminary studies in our model suggest that, hyperlipidemia maybe another contributing factor in the connection between obesity/Type 2 diabetes and cancer and cancer metastases. This model, using breast and colon cancer, will be studied to identify the causative connection between this metabolic disorder and cancer.
Overall the plan is to identify specific causality that will help design new therapeutic agents to deal with the growing problem of cancer in obese and diabetic patients."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine oncology breast cancer
- medical and health sciences clinical medicine oncology colorectal cancer
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
32000 Haifa
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.