Visualizing tolerance induction: behavior and function of regulatory T cells during the establishment of materno/fetal tolerance

Información del proyecto

VISTO

Identificador del acuerdo de subvención: 300901

Proyecto cerrado

Fecha de inicio 1 Marzo 2012

Fecha de finalización 28 Febrero 2014

Financiado con arreglo a

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coste total € 201 932,40

Aportación de la UE € 201 932,40

Coordinado por

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
France

Objetivo

The presence of foreign (allogenic) tissue in a host yields an immune response with the goal to destroy the tissue. During pregnancy, however, the semiallogenic fetus is allowed to grow within the maternal uterus. This ‘immunological paradox of pregnancy’ has received much attention because of its therapeutic implications in organ transplantation and autoimmune diseases.While it has recently been established that regulatory T cells are essential in establishing tolerogenic conditions during pregnancy, little is known about where and when T regulatory act.
I will characterize, using transgenic mouse lines and intra-vital two photon microscopy, the spatio-temporal characteristics of T regulatory cell recruitment at the materno/fetal interface. I will analyze the dynamics of cellular interactions between T regulatory cells with other immune system cells under physiological conditions and in a mouse model of spontaneous abortion. Finally, I will use a candidate gene approach to reveal similarities between molecular mechanisms of materno/fetal tolerance and tumor immune escape.
A better understanding of the mechanisms leading to materno/fetal tolerance will have therapeutic implications for the treatment of patients with recurrent spontaneous abortion and pre-eclampsia, for organ transplantation and for autoimmune diseases. Moreover, the interdisciplinary comparison of similarities between materno/fetal tolerance and tumor immune escape will provide novel experimental approaches for tumor immuno-therapy.

Ámbito científico

• medical and health sciences › basic medicine › immunology › autoimmune diseases
• medical and health sciences › clinical medicine › obstetrics
• medical and health sciences › basic medicine › immunology › immunotherapy
• medical and health sciences › clinical medicine › transplantation
• medical and health sciences › clinical medicine › embryology

Programa(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Tema(s)

• FP7-PEOPLE-2011-IIF - Marie Curie Action: "International Incoming Fellowships"

Convocatoria de propuestas

FP7-PEOPLE-2011-IIF
Consulte otros proyectos de esta convocatoria

Régimen de financiación

MC-IIF - International Incoming Fellowships (IIF)

Coordinador

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

Contacto administrativo

Thomas Wiest (Mr.)

• Aportación de la UE: € 201 932,40
• Dirección: Place Jussieu 4 ; 75252 PARIS ; Francia
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: Sin datos