Objective
"Obesity is the result of a mismatch between energy intake and energy expenditure. Part if excess calories will end up as fatty acids. The excess lipid will interfere with normal glucose homeostasis resulting in diabetes and other complications. Brown adipose tissue (BAT) is a tissue with high rates of lipid oxidation, making it an ideal organ burn excess fuel to control body weight. Recently it has been shown that BAT exists in humans being predominantly present in lean, young healthy humans opposed to humans that are obese.
Typically BAT is activated in cold exposure to increase body temperature. This signal is mediated via activation of transient receptor potential channels (i.e. extreme-cold receptor transient receptor potential channel member A1(TRPA1)) in nerve endings. The cold signal then reaches the hypothalamus via afferent neuronal pathways. Via activation of certain cerebral nuclei, a sympathetic response is produced that reaches end organs such as BAT. TRPA1 can also be activated by allyl-isothiocyanate (AITC, present in mustard). AITC in animal studies induces energy expenditure. The end transient receptor potential cation channel subfamily V member (1 TRPV1), is an other receptor that activates energy expenditure via the natural compound capsaicin.
We suggest that the activation of BAT is a promising target to increase energy expenditure in humans. The aim of this fellowship is to investigate the activation of energy expenditure via various protocols such as cold and the administration of AITC and capsaicin in healthy humans and obese subjects.
Included subjects will undergo test protocols under two temperature conditions (thermoneutrality and cold), AITC and capsaicin administration. In these protocols we will also assess the role of the sympathetic nervous system (beta-blockade), glucose and lipid metabolism (stable isotope studies) and imaging by infrared thermography and fluorodeoxy glucose positron-emission tomography."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.