Objective
"This project will study the role of SMOC2 in the biology and pathology of synovial joints with specific attention towards osteoarthritis (OA), one of the most common chronic diseases. SMOC2 is a novel secreted protein that can interact with bone morphogenetic protein (BMP) and Wingless-like (Wnt) signaling key pathways in joint development, homeostasis, disease and repair. We will use a translational research approach combining in vitro data with mechanistic insights obtained in a well characterized animal model and then linking this to ex vivo patient data. In addition, SMOC2 and modified versions of the protein will be specifically tested for therapeutic applications. If successful, this project will teach us how SMOC2 interacts with BMP and Wnts in joint biology and disease. The aim is to define SMOC2 biology as a therapeutic target to improve diagnosis, treatment and prognosis of osteoarthritis.
Dr. Cailotto, the experience researcher candidate for the fellowship, will be trained in the use of animal models and dealing with translational research hypotheses. He will also benefit from complementary skills training and interactions with industry in order to gain further maturity and independence as a researcher. This additional training will be beneficial to his career as well as to the European Research Area as there is a great societal need for translational researcher in the field of chronic joint diseases able to make links between basic biology and clinical questions. The project pays specific attention to cross-sectorial interactions and communication with the scientific community as well as with the primary stakeholders for osteoarthritis: the patients and population at risk."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3000 LEUVEN
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.