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Contenido archivado el 2024-05-28

SMOC2 in osteoarthritis

Objetivo

"This project will study the role of SMOC2 in the biology and pathology of synovial joints with specific attention towards osteoarthritis (OA), one of the most common chronic diseases. SMOC2 is a novel secreted protein that can interact with bone morphogenetic protein (BMP) and Wingless-like (Wnt) signaling key pathways in joint development, homeostasis, disease and repair. We will use a translational research approach combining in vitro data with mechanistic insights obtained in a well characterized animal model and then linking this to ex vivo patient data. In addition, SMOC2 and modified versions of the protein will be specifically tested for therapeutic applications. If successful, this project will teach us how SMOC2 interacts with BMP and Wnts in joint biology and disease. The aim is to define SMOC2 biology as a therapeutic target to improve diagnosis, treatment and prognosis of osteoarthritis.
Dr. Cailotto, the experience researcher candidate for the fellowship, will be trained in the use of animal models and dealing with translational research hypotheses. He will also benefit from complementary skills training and interactions with industry in order to gain further maturity and independence as a researcher. This additional training will be beneficial to his career as well as to the European Research Area as there is a great societal need for translational researcher in the field of chronic joint diseases able to make links between basic biology and clinical questions. The project pays specific attention to cross-sectorial interactions and communication with the scientific community as well as with the primary stakeholders for osteoarthritis: the patients and population at risk."

Ámbito científico (EuroSciVoc)

Programa(s)

Tema(s)

Convocatoria de propuestas

FP7-PEOPLE-2011-IEF
Consulte otros proyectos de esta convocatoria

Régimen de financiación

MC-IEF - Intra-European Fellowships (IEF)

Coordinador

KATHOLIEKE UNIVERSITEIT LEUVEN
Aportación de la UE
€ 169 800,00
Dirección
OUDE MARKT 13
3000 Leuven
Bélgica
Región
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
Sin datos