Objective
Interactions between neurons and glial cells underlie the normal development, structure and function of the nervous system. Perturbation of this communication occurs during injury, in acquired or hereditary neuropathic diseases of the central and peripheral nervous systems, and with ageing. However, the specific nature and the physiological significance of neuron-glia interactions remain largely unknown. We propose here the use of a microfluidic co-culture platform to characterize and investigate the role of non-synaptic responses of glial cells following stimulation of neuronal activity. In particular, we will co-culture neurons and glial cells of the peripheral nervous system, and monitor glia-specific changes at the transcriptome- and the secretome-levels, after manipulation of the electrical activity of neurons. We will subsequently interfere with the identified signaling pathways, and study effects on neuronal structure and function. Following this in vitro approach, we expect to identify potential mediators of the axon-glia communication and decipher their role in maintaining the nervous system integrity and function.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.