Objective The goal of this project is to control signalling in the mammalian nervous system with ‘hi-jacked’ microbial receptor proteins. We will first compile a comprehensive library of microbial ligand-gated ion channels (m-LGICs), and we will then characterize the function of selected m-LGICs in molecular detail. In order to exploit the technological potential of m-LGICs, we will employ them to control signalling in a model of epilepsy. This project provides the first systematic characterization of m-LGIC diversity and the first application thereof for the re-engineering of biological systems. It will develop the orthogonal manipulation of neuronal electrical signals with potential for treating neurological diseases. It will also open the door to new agents that target microbes threatening health and agriculture. The applicant Harald Janovjak from the University of California Berkeley has taken up a five-year post at the Institute of Science and Technology Austria. He will receive project support, mentoring and career development to build up an independent research group, supervise students and maintain international collaborations. His background brings new research opportunities to Europe and seamlessly integrates with research at the host institution. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologyepilepsynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsagricultural sciencesagriculture, forestry, and fisheriesagriculture Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Call for proposal FP7-PEOPLE-2011-CIG See other projects for this call Funding Scheme MC-CIG - Support for training and career development of researcher (CIG) Coordinator INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Address Am campus 1 3400 Klosterneuburg Austria See on map Region Ostösterreich Niederösterreich Wiener Umland/Nordteil Activity type Higher or Secondary Education Establishments Administrative Contact Willetta Barnhill (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
