Obiettivo The goal of this project is to control signalling in the mammalian nervous system with ‘hi-jacked’ microbial receptor proteins. We will first compile a comprehensive library of microbial ligand-gated ion channels (m-LGICs), and we will then characterize the function of selected m-LGICs in molecular detail. In order to exploit the technological potential of m-LGICs, we will employ them to control signalling in a model of epilepsy. This project provides the first systematic characterization of m-LGIC diversity and the first application thereof for the re-engineering of biological systems. It will develop the orthogonal manipulation of neuronal electrical signals with potential for treating neurological diseases. It will also open the door to new agents that target microbes threatening health and agriculture. The applicant Harald Janovjak from the University of California Berkeley has taken up a five-year post at the Institute of Science and Technology Austria. He will receive project support, mentoring and career development to build up an independent research group, supervise students and maintain international collaborations. His background brings new research opportunities to Europe and seamlessly integrates with research at the host institution. Campo scientifico scienze naturaliscienze biologicheneurobiologiascienze mediche e della salutemedicina di baseneurologiaepilessiascienze naturaliscienze biologichebiochimicabiomolecoleproteinescienze agricoleagricoltura, silvicoltura e pescaagricoltura Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Invito a presentare proposte FP7-PEOPLE-2011-CIG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-CIG - Support for training and career development of researcher (CIG) Coordinatore INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Indirizzo Am campus 1 3400 Klosterneuburg Austria Mostra sulla mappa Regione Ostösterreich Niederösterreich Wiener Umland/Nordteil Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Willetta Barnhill (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Contributo UE € 100 000,00
