Objective
Bone is a dynamic tissue that is constantly remodelled by the coupled activities of matrix-producing osteoblasts (OBs) and matrix-resorbing osteoclasts (OCs). Uncoupled bone remodelling may lead to low bone mass, causing osteoporosis and ultimately fractures, which constitute an increasing medical- and socio-economic problem. During fracture repair, a functional relationship exists between migrating OBs and the invading vasculature. To better understand physiological and disturbed bone remodelling, bone repair, and the communication between bone and vessels, it is crucially important to investigate molecular mechanisms regulating OB function, OB motility, and the bone-vascular niche. Resulting insights can then be used to improve the current cure of osteoporosis and fracture repair. Preliminary data revealed that the homeodomain protein Tg-interacting factor (Tgif) is an important regulator of OB function. Tgif-deletion in mice causes a low bone mass with spontaneous fractures, a disturbed bone marrow vascular network, and a compromised fracture healing with a reduced OB migration. Furthermore, Tgif-deficiency reduces the expression of the angiogenic factor Vegf-A by OBs and Tgif physically interacts with the cell motility regulator focal adhesion kinase (FAK), suggesting molecular mechanisms for the role of Tgif in vivo. Thus, the objectives of this proposal are to analyze the function of Tgif (i) in OB motility and FAK signalling, and (ii) in the regulation of Vegf-A expression and the bone-vascular niche. Both objectives will be accomplished using a state-of-the-art genetic approach in mice for the targeted deletion of Tgif in OBs and a complete set of complementary in vitro assays. Taken together, this project will establish Tgif as a novel physiological regulator of OB motility and the bone-vascular niche, thus reporting clinically important knowledge to improve the treatment of low bone mass diseases and fractures.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
20251 Hamburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.