Objective
Lung cancer is currently the most common malignancy and the leading cause of cancer-related death worldwide, varying significantly among geographical areas, sex of patients and distinct populations. Since 1970, incidence, and specific histological characteristics of lung cancer have been significantly modified; however, a disappointing survival rate still persists. A potential steroid relation of lung cancer might be of interest, in view of hormone replacement therapies and contraception strategies followed by a wide part of female population. Hence, the lung remains a favorite site for distant metastases of prostate and breast carcinomas and within this context, a well-established steroid receptor profiling could be crucial in differential diagnosis of primary lung tumors from metastatic foci. Aim of this study is the investigation of the function and the role of sex steroid receptors (both nuclear and extranuclear) in Non-Small Cell Lung Carcinomas (NSCLCs) and their possible prognostic, diagnostic and therapeutic relevance, in association with survival and therapeutic response of patients. Our approach includes three distinct but interrelated objectives: (1) Detection and action of ER and AR in NSCLC cell lines. In this objective, basic research on cells will be initiated. Different ER and AR (intracellular, nuclear and membrane-associated) receptors will be assayed by different methodologies, providing a receptor spectrum of each cell line and providing the more appropriate tools for the detection of the same parameters in human specimens; (2) performing pre-clinical pharmacology studies of SR implication in animal models; (3) validating our findings in clinical specimens and their relation with other established biomarkers, in view of their implementation as potential diagnostic, prognostic or tailored therapeutic targets.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences basic medicine pharmacology and pharmacy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
74 100 RETHIMNO
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.