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A novel micronutrient-based strategy to prevent hearing impairments: test and road to market for age-related hearing loss and preservation of residual hearing

Objective

Hearing impairment affects 600M people worldwide.  It greatly decreases quality of life, particularly in the elderly, and constitutes an unmet health and medical need.  Regeneration of sensory auditory hair cells is not available as a medical technology.  In concordance with this topic call, we propose a novel strategy based on the development of a new technology, a micronutrient formulation implemented as a pill, to prevent damage, and perhaps recovery of auditory hair cells.  This SME-driven program is based on the scientific rationale that free radical formation and blood flow reduction underlie cell death in sensory systems in response to environmental stress and with aging.  In the auditory system, the stress of intense noise, drugs, cochlear implantation and aging lead to excess free radical formation, blood flow reduction, inner ear sensory cell loss, and irreversible hearing impairment.  Our aim is to demonstrate that a proprietary combination of antioxidants (Vitamins A, C, E) and a vasodilator (Mg++) effectively prevent/treat: 1) hearing loss in the elderly and 2) loss of residual hearing in the elderly and patients receiving cochlear implants.  A combination of human trials and animal studies will create a pathway to market and effectively translate this new technology to human application.

Call for proposal

FP7-HEALTH-2012-INNOVATION-2
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Coordinator

UNIVERSIDAD DE CASTILLA - LA MANCHA
Address
Calle Altagracia 50
13071 Ciudad Real
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 602 276
Administrative Contact
Maria-Llanos Carrión-Varela (Ms.)

Participants (4)

HHSE-AUDIPROTEC SOCIEDAD LIMITADA
Spain
EU contribution
€ 2 994 500
Address
Paseo De La Innovacion 1
02006 Albacete
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Barry Seifer (Mr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 736 040
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
HANNOVER CLINICAL TRIAL CENTER GMBH
Germany
EU contribution
€ 290 280
Address
Carl Neuberg Str 1 K 27 Oe 9751
30625 Hannover
Activity type
Research Organisations
Administrative Contact
Thomas Fink (Mr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 473 504
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Miles Davies (Dr.)