Objetivo Over the last decade, kinases have emerged as attractive therapeutic targets in inflammatory diseases. Numerous efforts in the pharmaceutical community are directed towards the discovery of small molecule inhibitors that regulate kinase function.A number of issues need to be addressed when considering kinases as targets in inflammation. The combination of efficacy and favourable safety profile is often key for the successful treatment of chronic inflammatory and/or autoimmune diseases with kinase inhibitors.The LSE (Low Systemic Exposure) approach is a Creabilis proprietary technology that generates innovative molecules with unique physico-chemical and pharmacological characteristics. LSE molecules are ‘topical by design’ molecules that share some common features. They combine high local concentration with poor systemic absorption and distribution. If absorbed, LSE molecules are rapidly eliminated from the systemic circulation (very short plasma half-life), thus generating no/low side effects. LSE approach has already been clinically validated through CT327, a selective topical kinase inhibitor that recently reported positive Phase 2a data in both psoriasis and atopic dermatitis.This project will combine Creabilis experience and know-how on LSE modification of molecules with the sound systems biology and network pharmacology expertise of the University of Dundee to generate and bring to preclinical development a new generation of innovative molecules optimised for topical treatment of inflammatory diseases, such as psoriasis, atopic dermatitis and inflammatory bowel disease.The generated lead compound(s) will be characterized by minimal or no systemic toxicity combined with efficacy and optimised selectivity. This would tremendously widen the range of patients affected by inflammatory pathologies that could benefit of topical kinase inhibition as a therapy and provide an innovative concept for new medicines to be developed. Ámbito científico medical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesclinical medicinegastroenterologyinflammatory bowel diseasemedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesbasic medicinepathologymedical and health sciencesbasic medicinepharmacology and pharmacy Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2012.2.1.2-1 - Systems medicine: SME-driven research applying systems biology approaches to address medical and clinical needs Convocatoria de propuestas FP7-HEALTH-2012-INNOVATION-1 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador CREABILIS THERAPEUTICS SRL Aportación de la UE € 896 674,26 Dirección VIA RIBES 5 10010 COLLERETTO GIACOSA TO Italia Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Silvio Traversa (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo SERICHIM S.r.l. Italia Aportación de la UE € 178 254,00 Dirección Piazzale Marinotti 1 33050 Torviscosa Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Pietro Delogu (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO La participación finalizó Países Bajos Aportación de la UE € 26 005,50 Dirección ANNA VAN BUERENPLEIN 1 2595 DA Den Haag Ver en el mapa Región West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Tipo de actividad Research Organisations Contacto administrativo Robert Ostendorf (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITY OF DUNDEE Reino Unido Aportación de la UE € 146 280,00 Dirección Nethergate DD1 4HN Dundee Ver en el mapa Región Scotland Eastern Scotland Angus and Dundee City Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ian Robertson (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos TNO TRISKELION BV La participación finalizó Países Bajos Aportación de la UE Sin datos Dirección UTRECHTSEWEG 48 3704 HE ZEIST Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo John Hoebe (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos KWS BIOTEST LIMITED Reino Unido Aportación de la UE € 202 467,24 Dirección MEDICAL SCIENCES BUILDING UNIVERSITY WALK BS8 1TD BRISTOL Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Vicky Chen (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
