Obiettivo Over the last decade, kinases have emerged as attractive therapeutic targets in inflammatory diseases. Numerous efforts in the pharmaceutical community are directed towards the discovery of small molecule inhibitors that regulate kinase function.A number of issues need to be addressed when considering kinases as targets in inflammation. The combination of efficacy and favourable safety profile is often key for the successful treatment of chronic inflammatory and/or autoimmune diseases with kinase inhibitors.The LSE (Low Systemic Exposure) approach is a Creabilis proprietary technology that generates innovative molecules with unique physico-chemical and pharmacological characteristics. LSE molecules are ‘topical by design’ molecules that share some common features. They combine high local concentration with poor systemic absorption and distribution. If absorbed, LSE molecules are rapidly eliminated from the systemic circulation (very short plasma half-life), thus generating no/low side effects. LSE approach has already been clinically validated through CT327, a selective topical kinase inhibitor that recently reported positive Phase 2a data in both psoriasis and atopic dermatitis.This project will combine Creabilis experience and know-how on LSE modification of molecules with the sound systems biology and network pharmacology expertise of the University of Dundee to generate and bring to preclinical development a new generation of innovative molecules optimised for topical treatment of inflammatory diseases, such as psoriasis, atopic dermatitis and inflammatory bowel disease.The generated lead compound(s) will be characterized by minimal or no systemic toxicity combined with efficacy and optimised selectivity. This would tremendously widen the range of patients affected by inflammatory pathologies that could benefit of topical kinase inhibition as a therapy and provide an innovative concept for new medicines to be developed. Campo scientifico scienze mediche e della salutescienze della salutemalattie infiammatoriescienze mediche e della salutemedicina clinicagastroenterologiamalattia infiammatoria intestinalescienze mediche e della salutemedicina di baseimmunologiamalattie autoimmuniscienze mediche e della salutemedicina di basepatologiascienze mediche e della salutemedicina di basefarmacologia e farmacia Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2012.2.1.2-1 - Systems medicine: SME-driven research applying systems biology approaches to address medical and clinical needs Invito a presentare proposte FP7-HEALTH-2012-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore CREABILIS THERAPEUTICS SRL Indirizzo Via ribes 5 10010 Colleretto giacosa to Italia Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Silvio Traversa (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Contributo UE € 896 674,26 Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto SERICHIM S.r.l. Italia Contributo UE € 178 254,00 Indirizzo Piazzale marinotti 1 33050 Torviscosa Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Pietro Delogu (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO Partecipazione conclusa Paesi Bassi Contributo UE € 26 005,50 Indirizzo Anna van buerenplein 1 2595 DA Den haag Mostra sulla mappa Regione West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Tipo di attività Research Organisations Contatto amministrativo Robert Ostendorf (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window UNIVERSITY OF DUNDEE Regno Unito Contributo UE € 146 280,00 Indirizzo Nethergate DD1 4HN Dundee Mostra sulla mappa Regione Scotland Eastern Scotland Angus and Dundee City Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ian Robertson (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window TNO TRISKELION BV Partecipazione conclusa Paesi Bassi Contributo UE € 0,00 Indirizzo Utrechtseweg 48 3704 HE Zeist Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo John Hoebe (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window KWS BIOTEST LIMITED Regno Unito Contributo UE € 202 467,24 Indirizzo Medical sciences building university walk BS8 1TD Bristol Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Vicky Chen (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window
