Skip to main content

Development of an integrated SPECT/MRI system for enhanced stratification of brain tumour patients prior to patient-specific radio-chemo therapy and early assessment of treatment efficacy

Objective

The purpose of the project INSERT is to provide clinically relevant stratification and improved personalized radio-chemo therapy for brain tumour patients using a specifically developed multi-modality imaging tool. The system will also be used for early assessment of treatment efficacy. The initial focus will be on patients with glioma but there is future potential to target a range of tumours in the head and neck region. The proposed system is based on the development of a novel SPECT (Single Photon Emission Computed Tomography) system, suitable for insertion in the bore of an existing MRI (Magnetic Resonance Imaging) system, a cost-effective solution for widespread application. The combined system will allow the simultaneous measurement of anatomical (MRI) and functional (SPECT & MRI) information and the evaluation of their correlation in space and time. The SPECT design will enable acquisition of fast dynamic studies, with possibility for simultaneous measurement using multiple radionuclides (emitting at different energies), a distinct advantage compared to positron emission tomography (PET). This property can allow in-vivo simultaneous visualisation of spectrally resolved molecular and biochemical tumour properties. The stationary SPECT system is based on recently developed innovative gamma-ray detectors made with Silicon Drift Photodetectors, technology that achieves high-spatial resolution and is compatible with MRI thanks to the use of a silicon photodetector instead of photomultiplier tubes. The multi-modality SPECT/MRI imaging here proposed will apply a fully translational, vertical integration of research and development from technology design through preclinical models to clinical validation.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

POLITECNICO DI MILANO
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 715 000
Administrative Contact
Fabio Conti (Mr.)

Participants (10)

Mediso Orvosi Berendezes Fejleszto es Szerviz Kft.
Hungary
EU contribution
€ 1 100 000
Address
Alsotorokvesz 14
1022 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Erzsébet Zelei (Ms.)
FONDAZIONE BRUNO KESSLER
Italy
EU contribution
€ 400 000
Address
Via Santa Croce 77
38122 Trento
Activity type
Research Organisations
Administrative Contact
Umberto Silvestri (Mr.)
NUCLEARFIELDS INTERNATIONAL BV
Netherlands
EU contribution
€ 200 000
Address
Akkervoortweg 7-11
5827AP Vortum Mullem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gerjan Roelofs (Mr.)
MRI. TOOLS GMBH
Germany
EU contribution
€ 500 000
Address
Robert Rossle Strasse 10
13125 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thoralf Niendorf (Prof.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 575 622,70
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Mrs.)
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
EU contribution
€ 250 000
Address
Via Olgettina 58
20132 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Rosa Pedrazzi (Dr.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 270 000
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Antonia Giofrè (Dr.)
CROMED KUTATO ES SZOLGALTATO KOZPONTOK KFT
Hungary
EU contribution
€ 350 000
Address
Baross Utca 91 95
1047 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Péter Riczu (Mr.)
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Italy
EU contribution
€ 115 000
Address
Via Giuseppe Mussi 1
20154 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carla Finocchiaro (Ms.)
UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 124 377,30
Address
Euston Road 250
NW1 2PG London
Activity type
Research Organisations
Administrative Contact
Joe Mwanza (Mr.)