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Development of an integrated SPECT/MRI system for enhanced stratification of brain tumour patients prior to patient-specific radio-chemo therapy and early assessment of treatment efficacy

Obiettivo

The purpose of the project INSERT is to provide clinically relevant stratification and improved personalized radio-chemo therapy for brain tumour patients using a specifically developed multi-modality imaging tool. The system will also be used for early assessment of treatment efficacy. The initial focus will be on patients with glioma but there is future potential to target a range of tumours in the head and neck region. The proposed system is based on the development of a novel SPECT (Single Photon Emission Computed Tomography) system, suitable for insertion in the bore of an existing MRI (Magnetic Resonance Imaging) system, a cost-effective solution for widespread application. The combined system will allow the simultaneous measurement of anatomical (MRI) and functional (SPECT & MRI) information and the evaluation of their correlation in space and time. The SPECT design will enable acquisition of fast dynamic studies, with possibility for simultaneous measurement using multiple radionuclides (emitting at different energies), a distinct advantage compared to positron emission tomography (PET). This property can allow in-vivo simultaneous visualisation of spectrally resolved molecular and biochemical tumour properties. The stationary SPECT system is based on recently developed innovative gamma-ray detectors made with Silicon Drift Photodetectors, technology that achieves high-spatial resolution and is compatible with MRI thanks to the use of a silicon photodetector instead of photomultiplier tubes. The multi-modality SPECT/MRI imaging here proposed will apply a fully translational, vertical integration of research and development from technology design through preclinical models to clinical validation.

Invito a presentare proposte

FP7-HEALTH-2012-INNOVATION-1
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Coordinatore

POLITECNICO DI MILANO
Indirizzo
Piazza Leonardo Da Vinci 32
20133 Milano
Italia

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Fabio Conti (Mr.)
Contributo UE
€ 715 000

Partecipanti (10)

Mediso Orvosi Berendezes Fejleszto es Szerviz Kft.
Ungheria
Contributo UE
€ 1 100 000
Indirizzo
Alsotorokvesz 14
1022 Budapest

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Erzsébet Zelei (Ms.)
FONDAZIONE BRUNO KESSLER
Italia
Contributo UE
€ 400 000
Indirizzo
Via Santa Croce 77
38122 Trento

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Tipo di attività
Research Organisations
Contatto amministrativo
Umberto Silvestri (Mr.)
NUCLEARFIELDS INTERNATIONAL BV
Paesi Bassi
Contributo UE
€ 200 000
Indirizzo
Akkervoortweg 7-11
5827AP Vortum Mullem

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Gerjan Roelofs (Mr.)
MRI. TOOLS GMBH
Germania
Contributo UE
€ 500 000
Indirizzo
Robert Rossle Strasse 10
13125 Berlin

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Thoralf Niendorf (Prof.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
Contributo UE
€ 575 622,70
Indirizzo
Gower Street
WC1E 6BT London

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Greta Borg-Carbott (Mrs.)
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italia
Contributo UE
€ 250 000
Indirizzo
Via Olgettina 58
20132 Milano

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Maria Rosa Pedrazzi (Dr.)
UNIVERSITA DEGLI STUDI DI MILANO
Italia
Contributo UE
€ 270 000
Indirizzo
Via Festa Del Perdono 7
20122 Milano

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Maria Antonia Giofrè (Dr.)
CROMED KUTATO ES SZOLGALTATO KOZPONTOK KFT
Ungheria
Contributo UE
€ 350 000
Indirizzo
Baross Utca 91 95
1047 Budapest

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Péter Riczu (Mr.)
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Italia
Contributo UE
€ 115 000
Indirizzo
Via Giuseppe Mussi 1
20154 Milano

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Carla Finocchiaro (Ms.)
UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST
United Kingdom
Contributo UE
€ 124 377,30
Indirizzo
Euston Road 250
NW1 2PG London

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Tipo di attività
Research Organisations
Contatto amministrativo
Joe Mwanza (Mr.)