Objectif Lung transplantation (LT) is the standard of care for selected patients with chronic respiratory failure. Chronic lung allograft dysfunction (CLAD) (i.e. “Bronchiolitis obliterans syndrome” (BOS) and “Restrictive Allograft Syndrome” (RAS)) represents a major health risk for LT recipients, requiring the use of heavy treatments and possible retransplantation. Observed in almost 50% of patients after 5 years post LT, it is currently impossible to predict the appearance of CLAD before the onset of first symptoms. This project aims to develop the SysCLAD model which will allow to predict, within the 1st year post LT, the recipients at risk of developing CLAD by 3 years post LT. Building upon available data from the cohort of lung transplantation (COLT, recruited since mid-2009), this project will integrate new LT recipients to form the European cohort of lung transplantation (ECOLT). The SysCLAD prediction tool will be based on a mathematical model developed through a system biology approach integrating both clinical and biological data collected from a total of 400 LT recipients. The model will be validated on the first 200 LT recipients (3 years follow-up at project start) and refined using the new set of 200 LT data with 3 years follow-up by 2014. The aim is to identify and validate the signature of CLAD both at the clinical and molecular levels to allow for an early recognition and specific interventions in patients at risk of CLAD. The implementation of the model is expected to significantly improve the cost-effectiveness of post-LT treatments, limit the risk of graft rejection in LT recipients and, ultimately lead to an improved quality of life and a prolonged life expectancy of patients following LT. Finally, the SysCLAD model holds further great promises in the context of other chronic bronchial inflammatory diseases of major incidence such as severe asthma and Chronic Obstructive Pulmonary Disease (COPD) to predict decline in lung function. Champ scientifique medical and health sciencesclinical medicinepneumologyasthmamedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesclinical medicinetransplantationnatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2012.2.1.2-1 - Systems medicine: SME-driven research applying systems biology approaches to address medical and clinical needs Appel à propositions FP7-HEALTH-2012-INNOVATION-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Contribution de l’UE € 454 400,50 Adresse RUE DU BUGNON 21 1011 Lausanne Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Région lémanique Vaud Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contact administratif Thuy Oetli (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (8) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITE JOSEPH FOURIER GRENOBLE 1 France Contribution de l’UE € 522 200,00 Adresse Avenue Centrale, Domaine Universitaire 621 38041 GRENOBLE Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Yann Leroux (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES France Contribution de l’UE € 848 700,00 Adresse Allee de l'Ile Gloriette 5 44093 Nantes Voir sur la carte Région Pays de la Loire Pays de la Loire Loire-Atlantique Type d’activité Higher or Secondary Education Establishments Contact administratif Karine Botturi-Cavaillès (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée NOVADISCOVERY France Contribution de l’UE € 346 970,00 Adresse 1 PLACE GIOVANNI DA VERRAZZANO 69009 Lyon Voir sur la carte Région Auvergne-Rhône-Alpes Rhône-Alpes Rhône Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif François-Henri Boissel (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée BIOMAX INFORMATICS AG Allemagne Contribution de l’UE € 243 765,75 Adresse ROBERT KOCH STRASSE 2 82152 STEINKIRCHEN Voir sur la carte Région Bayern Oberbayern München, Landkreis Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Dieter Maier (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée EUROFINS GENOMICS EUROPE PHARMA AND DIAGNOSTICS PRODUCTS & SERVICES SANGER PCR GMBH Allemagne Contribution de l’UE € 416 616,00 Adresse JAKOB STADLER PLATZ 7 78467 Konstanz Voir sur la carte Région Baden-Württemberg Freiburg Konstanz Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Janet Kenklies (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée FINOVATIS France Contribution de l’UE € 101 000,00 Adresse 62 RUE DE BONNEL 69003 Lyon Voir sur la carte Région Auvergne-Rhône-Alpes Rhône-Alpes Rhône Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif David Koubi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée University of Zurich Suisse Contribution de l’UE € 37 500,00 Adresse RAMISTRASSE 71 8006 ZURICH Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Andreas Ledergerber (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée HLA ET MEDECINE France Contribution de l’UE € 27 999,75 Adresse Avenue Claude Vellefaux 1 75010 Paris Voir sur la carte Type d’activité Research Organisations Contact administratif Charles Auffray (Dr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée