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A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co-morbidities; hypertriglyceridemia and low HDL-cholesterol

Objective

Through combining basic pre-clinical and clinical research, network analysis and computational modelling, RESOLVE aims at resolving the disturbed dynamics and mechanisms underlying the high triglyceride (HTG) and low high-density lipoprotein cholesterol (HDL-C) phenotype and insulin resistance in patients with metabolic syndrome (MetS) and its associated co-morbidities (cardiovascular disease, CVD; type 2 diabetes, T2DM; non-alcoholic fatty liver disease, NAFLD). RESOLVE will deliver on 6 specific objectives:
i) build a computational model for analyzing the kinetics of plasma lipids, lipoproteins and their interactions with glucose metabolism.
ii) apply the iterative systems biology cycle for calibrating, validating and improving the computational model in dedicated studies in mice
iii) build, calibrate and validate the computational model for use in humans.
iv) analyze – based on model and experimental data – which processes in the murine metabolic network regulate the physiological response to perturbations in lipid, lipoprotein and glucose metabolism and how these interact.
v) analyze – based on model and experimental data – which processes in the human metabolic network regulate the physiological response to perturbations in lipid, lipoprotein and glucose metabolism and how these interact
vi) use the human model to identify network-based drug targets aimed at restoring the metabolic dyslipidemia and glycemic control in patients with MetS and associated comorbidities.
RESOLVE 60-months project will result into a novel strategy for development of therapeutic strategies for MetS patients with T2DM, NAFLD or CVD.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
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Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 489 901
Administrative Contact
Marijke Bijker-Schreurs (Ms.)

Participants (13)

NOVAMEN SAS

Participation ended

France
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marie-Laure Muiras (Dr.)
TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 943 898
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rob Debeij (Mr.)
University of Zurich
Switzerland
EU contribution
€ 1 221 793
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arnold Von Eckardstein (Prof.)
INSTITUT PASTEUR DE LILLE FONDATION
France
EU contribution
€ 771 602
Address
Rue Du Professeur Calmette 1
59019 Lille
Activity type
Research Organisations
Administrative Contact
Fabienne Jean (Dr.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 792 600
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jörg Heeren (Prof.)
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 808 498
Address
N Plastira Str 100
70013 Irakleio
Activity type
Research Organisations
Administrative Contact
Zinovia Papatheodorou (Mrs.)
GENEXPLAIN GMBH
Germany
EU contribution
€ 584 599
Address
Am Exer 19 B
38302 Wolfenbuttel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Holger Michael (Dr.)
Centrum fur Angewandte Nanotechnologie (CAN) GmbH
Germany
EU contribution
€ 373 600
Address
Grindelallee 117
20146 Hamburg
Activity type
Research Organisations
Administrative Contact
Frank Schröder-Oeynhausen (Dr.)
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Belgium
EU contribution
€ 591 050
Address
Drie Eikenstraat 655
2650 Edegem
Activity type
Research Organisations
Administrative Contact
Luc Van Gaal (Prof.)
ACIES Consulting Group SAS
France
EU contribution
€ 204 834
Address
Rue De La République 69
69002 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marie-Laure Muiras (Dr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 962 241
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Erwin J. Van Der Meijden (Mr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 400 000
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ellen Rydberg (Dr.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 403 758
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Berg (Mrs.)