Objective MAILPAN (MAcroencapsulation of PANcreatic Islets) is a prototype of bioartificial pancreas usable in the human designed to treat type 1 diabetic patients. The prototype was developed along different stages since 1996 and led to the creation of the SME called Defymed in 2011. Next step is now to bring the prototype to the pre-clinical and clinical phases necessary to the ensuing commercialization of MAILPAN whose ultimate goal is to improve the life of at least 20 million persons in the world while providing positive effects on healthcare management and expenses, the environment and the competitiveness of the biomaterials industry.In order to reach this goal, CeeD and Defymed gathered a consortium made of seven partners from academia, clinical/public health research sector and industry/SMEs from three different European countries –Belgium, France and UK. The expertise gathered include encapsulation techniques, islet isolation, cell engineering, islet transplantation, islet preconditioning, surgical implantation, and medium formulation; items that are complementary and necessary to the implementation of the present project proposal.The project proposal of a 48-month duration intends to bring the most modern and up to date improvements that the bioartificial pancreas still needs and can receive such as to enhance cells survival inside the device by formulating a new adapted cell culture medium, to further lower the rejection risk by studying the biocompatibility and anti-inflammatory mechanisms, to test the prototype in small and large animal models, and to secure its further use in humans. Safety and bio-compatibility of MAILPAN device combined to the islets/pseudo-islets, will be assessed, in respect to the applied regulatory directives. Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinetransplantationengineering and technologyindustrial biotechnologybiomaterials Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.2.4.3-1 - Innovative approach to manage diabetes Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator CENTRE EUROPEEN D'ETUDE DU DIABETE EU contribution € 812 317,60 Address BOULEVARD RENE LERICHE 67200 STRASBOURG France See on map Region Grand Est Alsace Bas-Rhin Activity type Other Administrative Contact Severine Sigrist (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all AvantiCell Science Ltd United Kingdom EU contribution € 484 927,20 Address GIBBSYARD BUILDING KA6 5HW Ayr See on map Region Scotland Southern Scotland South Ayrshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Colin Wilde (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER France EU contribution € 425 000,00 Address AVENUE DU DOYEN GASTON GIRAUD 191 34000 Montpellier See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Research Organisations Administrative Contact Valérie Handweiler (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 1 073 262,00 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Linda Pialek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEFYMED France EU contribution € 636 050,00 Address 9 RUE ALBERT CALMETTE 67200 Strasbourg See on map Region Grand Est Alsace Bas-Rhin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Richard Bou Aoun (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HUMAN CELL DESIGN France EU contribution € 601 400,00 Address PLACE PIERRE POTIER CENTRE PIERRE POTIER CANCEROPOLE ENTREE B 1 31000 Toulouse See on map Region Occitanie Midi-Pyrénées Haute-Garonne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anne-Fabienne Weitsch (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SARL ENDOCELLS Participation ended France EU contribution No data Address Boulevard Saint Germain 216 75007 Paris See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anne-Fabienne Weitsch (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium EU contribution € 1 136 546,00 Address PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve See on map Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Higher or Secondary Education Establishments Administrative Contact Pierre Gianello (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data