Objective
The environment of a given organism determines the dynamics of gene expression, post-translational modifications of proteins and their interactions. Proteomics and genomics approaches now allow capturing these dynamics, which govern the life of an organism. Proteomics is devoted to the systematic study of proteins in order to derive a global perspective of the structures, functions and regulatory mechanisms in biological systems. The proteome represents the entire protein complement of a cell or a tissue a t a given time, in given environmental, physiological and/or pathological conditions. The dynamic nature of the proteome constitutes one of the major hurdles of proteomics analyses. Whereas the analysis of a single sample can potentially provide all the genetic information about an organism, a multitude of analyses in various conditions are necessary for proteome studies. Recent years have seen an intensive development in proteomics methodologies.
Among these, accurate mass and time (AMT) tag based proteomic is particularly promising to provide extensive proteome coverage with high throughput. An AMT tag database is established by using standard proteomics methods to identify peptides and their parent proteins. Identifications are then validated using accurate masses obtained by Fourier Transform Mass Spectrometry (FTMS) and Liquid Chromatography (LC) retention times. The AMT tag database obviates the need for MS/MS in all subsequent analyses, providing the basis for throughput improvements. We are getting involved in a large-scale effort to implement and develop AMT-tag based methods.
Our strategy includes new technological developments and biological applications. We plan to improve the method's quantitative ability, and to promote the use of alternative ion dissociation methods to study post-translational modifications. Initial applications include studies of the membrane from A. thaliana chloroplasts and of a mouse model of the graft vs host disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences zoology invertebrate zoology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.