Objective
Fungi such as Candida albicans are ubiquitous colonizers of human skin and mucosa. Fungal pathogens invade the host when host defence is diminished, and the combination of fungal and bacterial colonization modulates mucosal and systemic immune responses. Little is known of the complex interaction between fungal and bacterial colonization, as well as between these two and the host genome and immunity. The Hypothesis of this proposal is that immunity to C. albicans is determined by the interaction between fungal colonization (mycobiome), bacterial flora (bacteriome), and the genetic background of the host (genome). This interaction is distorted in patients with fungal infections, and the identification of these imbalances will lead to novel therapeutic targets.
The Key Objectives are:
1) To map the landscape of interaction between the fungal colonization (mycobiome), bacterial flora (bacteriome) and the genetic and immunological make-up of the host (functional genome).
2) To assess the dysregulation of these interactions in patients with the two most important Candida infections: recurrent vulvovaginal candidiasis (RVVC) and disseminated candidiasis.
Methodological approach:
- the mycobiome and bacteriome will be determined on the skin and mucosal surfaces of healthy volunteers, RVVC and disseminated candidiasis patients.
- functional assessment of antifungal immune mechanisms will be correlated with the mycobiome/bacteriome, and with the host genetic variation (genome).
- validation of the functional interactions of microbial communities with host immunity using focused genotyping and follow-up pathway activity screening in human cell cultures and experimental models.
- microbiome/functional genome dysregulation between healthy individuals and patients with muocosla and systemic candidiasis will be identified.
Expected results: Proof-of-concept in-vitro and experimental studies will validate these interactions as novel diagnostic and/or therapeutic targets.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences infectious diseases
- natural sciences biological sciences microbiology mycology
- medical and health sciences basic medicine immunology
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-StG_20111109
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.