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The interaction of thiols and thiyl radicals with DNA model systems

Objectif

Thiols (RSH) play an important role in the living cells taking part in the chemical repair reactions of radical damages induced in DNA. As the result of such repair thiyl radicals (RS) are formed. The aim of this project is to broaden the knowledge concer ning kinetics of chemical repair reactions of nucleobase derived radicals by thiols. Moreover, to study in detail photosensitized generation of thiyl radicals from thiols and their possible interaction with unsaturated bonds in purines. In continuation of the former RTN project, by means of pulse radiolysis behaviour of the nucleobase-derived radicals with defined structures in the presence of thiols will be investigated. On this basis the repair rate constants will be determined. Photosensitized generation of thiyl radicals will be studied by laser flash photolysis technique. Behaviour of thiyl radicals in the presence of purines will be observed in order to answer the question whether thiyl radicals interact with unsaturated bonds in purine bases.

Champ scientifique (EuroSciVoc)

Mots‑clés

Thème(s)

Appel à propositions

FP6-2004-MOBILITY-11
Voir d’autres projets de cet appel

Régime de financement

ERG - Marie Curie actions-European Re-integration Grants

Coordinateur

THE UNIVERSITY OF ADAM MICKIEWICZ
Contribution de l’UE
Aucune donnée
Coût total
Aucune donnée