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Micro/nanosensors for early cancer warning system - diagnostic and prognostic information

Objective

"Oncologists still rely heavily on biological characterisation of tumours and a limited number of biomarkers which have demonstrated clinical utility. Routine cancer diagnostic tools may not be always sensitive enough and may only detect proteins at levels corresponding to an advanced stage of the disease. Recently, new genomic and proteomic molecular tools (molecular signatures) are being employed which include genetic and epigenetic signatures, changes in gene expression, protein profiles and post-translational modification of proteins. Such advanced diagnostic tools are not always readily adapted to clinical cancer screening due to their complexity, costs and the requirement for highly-qualified operators. Novel bioanalytical methodologies for detection of specific biomarkers/ biomolecules, based on nanostructured electronic sensors (rapid, sensitive devices capable of miniaturisation and deployment on site or in small clinics), fulfill the necessary requirements and have the potential to compliment time- and labour consuming clinical analysers used in medical laboratories currently. The primary objective of this proposal, therefore, is to gather together an international and interdisciplinary consortium of ten research teams from EU Member States, Third (including ENP) countries with EU agreements on S&T, in order to share and jointly exploit knowledge and expertise in the development of micro/nanosensors as tools in early cancer diagnosis. A key scientific target is the realisation of intelligent electronic devices which respond to biomolecules such as formaldehyde, amines, metal ions, saccharides, activities of amine oxidases, arginase and glutathione-S-transferase. This will entail design, development and characterisation of nano-scale transducers suitable for testing in clinical samples."

Call for proposal

FP7-PEOPLE-2012-IRSES
See other projects for this call

Funding Scheme

MC-IRSES - International research staff exchange scheme (IRSES)

Coordinator

INSTITUTE OF TECHNOLOGY TALLAGHT
Address
Old Blessington Road
24 Tallaght Dublin 24
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 85 800
Administrative Contact
Eithne Dempsey (Prof.)

Participants (5)

UNIVERSITATEA DIN BUCURESTI
Romania
EU contribution
€ 117 000
Address
Soseaua Panduri 90
050663 Bucuresti
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Camelia Bala (Prof.)
UNIVERSITAT ROVIRA I VIRGILI
Spain
EU contribution
€ 87 000
Address
Carrer De Escorxador
43003 Tarragona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rosa Solà I Alberich (Dr.)
UNIVERSIDADE DE COIMBRA
Portugal
EU contribution
€ 87 700
Address
Paco Das Escolas
3001 451 Coimbra
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sergio Vicente (Mr.)
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 108 400
Address
Campus Valla
581 83 Linkoping
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anthony P.F. Turner (Prof.)
UNIVERSITE LYON 1 CLAUDE BERNARD
France
EU contribution
€ 98 900
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Javier Olaiz (Dr.)