Objective "Oncologists still rely heavily on biological characterisation of tumours and a limited number of biomarkers which have demonstrated clinical utility. Routine cancer diagnostic tools may not be always sensitive enough and may only detect proteins at levels corresponding to an advanced stage of the disease. Recently, new genomic and proteomic molecular tools (molecular signatures) are being employed which include genetic and epigenetic signatures, changes in gene expression, protein profiles and post-translational modification of proteins. Such advanced diagnostic tools are not always readily adapted to clinical cancer screening due to their complexity, costs and the requirement for highly-qualified operators. Novel bioanalytical methodologies for detection of specific biomarkers/ biomolecules, based on nanostructured electronic sensors (rapid, sensitive devices capable of miniaturisation and deployment on site or in small clinics), fulfill the necessary requirements and have the potential to compliment time- and labour consuming clinical analysers used in medical laboratories currently. The primary objective of this proposal, therefore, is to gather together an international and interdisciplinary consortium of ten research teams from EU Member States, Third (including ENP) countries with EU agreements on S&T, in order to share and jointly exploit knowledge and expertise in the development of micro/nanosensors as tools in early cancer diagnosis. A key scientific target is the realisation of intelligent electronic devices which respond to biomolecules such as formaldehyde, amines, metal ions, saccharides, activities of amine oxidases, arginase and glutathione-S-transferase. This will entail design, development and characterisation of nano-scale transducers suitable for testing in clinical samples." Fields of science natural scienceschemical sciencesorganic chemistryaldehydesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsmedical and health sciencesclinical medicineoncologynatural scienceschemical sciencesorganic chemistryamines Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2012-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Call for proposal FP7-PEOPLE-2012-IRSES See other projects for this call Funding Scheme MC-IRSES - International research staff exchange scheme (IRSES) Coordinator INSTITUTE OF TECHNOLOGY TALLAGHT Address Old blessington road 24 Tallaght dublin 24 Ireland See on map Activity type Higher or Secondary Education Establishments Administrative Contact Eithne Dempsey (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 85 800,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITATEA DIN BUCURESTI Romania EU contribution € 117 000,00 Address Soseaua panduri 90 050663 Bucuresti See on map Region Macroregiunea Trei Bucureşti-Ilfov Bucureşti Activity type Higher or Secondary Education Establishments Administrative Contact Camelia Bala (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAT ROVIRA I VIRGILI Spain EU contribution € 87 000,00 Address Carrer de escorxador 43003 Tarragona See on map Region Este Cataluña Tarragona Activity type Higher or Secondary Education Establishments Administrative Contact Rosa Solà I Alberich (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDADE DE COIMBRA Portugal EU contribution € 87 700,00 Address Paco das escolas 3004-531 Coimbra See on map Region Continente Centro (PT) Região de Coimbra Activity type Higher or Secondary Education Establishments Administrative Contact Sergio Vicente (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Linköping University Sweden EU contribution € 108 400,00 Address Campus valla 581 83 Linköping See on map Activity type Higher or Secondary Education Establishments Administrative Contact Anthony P.F. Turner (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE LYON 1 CLAUDE BERNARD France EU contribution € 98 900,00 Address Boulevard du 11 novembre 1918 num43 69622 Villeurbanne cedex See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Higher or Secondary Education Establishments Administrative Contact Javier Olaiz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
