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Establishment of a cross continent consortium for enhancing regenerative medicine in skeletal tissues

Objective

Regenerative medicine (RM) is a critical need to establish in this century, in order to raise quality of life and reduce the cost of healthcare in our increasing aged populations. To do this there is a need for key research teams within and outside the EU to develop meaningful research collaborations and relationships at an institutional level. skelGEN brings together leading research institutions across disciplines in biology/engineering/computational modelling/orthopaedic research in the EU (UK, the Netherlands, Portugal) partnered with complementary experts in New Zealand. This collaboration will allow EU partner institutions to work in a coordinated way to address RM in the human skeleton, including bones, cartilage and tendons/ligaments. This work will range from basic science through to translational medicine and involves world experts, emerging scientists as well as young researchers.

The programme of exchanges and knowledge transfer is built around four main scientific themes that will feed into each other, to pursue of skelGEN’s long term mission successfully. These themes are centred on stem cells, scaffolds and medical devices, computerised modelling and overall evaluation. Advances in stem cell therapy are required, such as pluripotent stem cells that do not have the political and ethical concerns of embryonic stem cell populations. Dynamic scaffolds need to respond to their environment and can integrate bioactive factors, using biocompatible biomaterials e.g. producing hybrid constructs of titanium rods and bulk polymers, self-assembling short peptides etc. to create better tissue/implant interfaces powerful for potential new therapies in RM. We plan to use computational modelling to assist in the tissue engineering of scaffolds and cells/tissues in vitro and in vivo. Finally we will endeavour to standardise the evaluation techniques used to assess the biocompatibility of these future medical devices.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/medical biotechnology/tissue engineering
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /natural sciences/chemical sciences/polymer science
  • /engineering and technology/industrial biotechnology/biomaterials

Call for proposal

FP7-PEOPLE-2012-IRSES
See other projects for this call

Funding Scheme

MC-IRSES - International research staff exchange scheme (IRSES)

Coordinator

UNIVERSITY OF LEEDS
Address
Woodhouse Lane
LS2 9JT Leeds
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 29 400
Administrative Contact
Benjamin Williams (Mr.)

Participants (7)

UNIVERSIDADE DO MINHO
Portugal
EU contribution
€ 18 900
Address
Largo Do Paco
4704 553 Braga
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rui L. Reis (Prof.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 27 300
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Richard Oreffo (Prof.)
LOUGHBOROUGH UNIVERSITY
United Kingdom
EU contribution
€ 25 200
Address
Ashby Road
LE11 3TU Loughborough
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christopher Malins (Dr.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 16 800
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maggy Ovaa (Ms.)
INSTITUTO POLITECNICO DE LEIRIA
Portugal
EU contribution
€ 25 200
Address
Rua General Norton De Matos
2411-901 Leiria
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paulo Jorge Da Silva Bártolo (Prof.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 25 200
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gill Wells (Mr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms.)