Objective
Plant seeds are responsible for most of the world’s food supply and are important for the production of biofuels, fibers, and value-added chemicals. Seeds are also complex biological structures made of three genetically different tissues: the embryo, the endosperm that has nourishing functions and the seed coat that interfaces with the environment. The seed coat of the model plant Arabidopsis thaliana can be divided into five structurally different layers. The innermost layer, the endothelium, accumulates proanthocyanidins, strong antioxidant compounds that create a protective chemical and physical barrier, and coordinates seed growth in concert with the endosperm, embryo and other seed coat layers. From an applied perspective, the endothelium is responsible for the important agronomic trait of seed quality and growing evidence suggests that seed proanthocyanidins are beneficial for human health. Therefore, a deeper understanding of the molecular mechanisms underlying seed coat development might have profound scientific and practical implications.
I propose a project aimed at elucidating the regulatory gene networks responsible for the development of the endothelium in A. thaliana. In order to achieve this goal, I propose to first dynamically profile the endothelium transcriptome through the INTACT method for individual cell types isolation. Second, I plan to start mapping regulatory gene networks by characterizing the downstream target genes of the TRANSPARENT TESTA 16 (TT16) transcription factor, known to play a key role in A. thaliana endothelium development. This study will be combined with a complementary analysis of TT16 protein complexes. Finally, the data obtained by each of the three project steps will be cross-analyzed in order to gain a broader understanding of the molecular processes underlying endothelium development and discover potentially novel genes involved in seed coat development to be further characterized.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering fibers
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine embryology
- engineering and technology industrial biotechnology biomaterials biofuels
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
75007 PARIS CEDEX 07
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.