Objective Alzheimer’s disease is a neurodegenerative disease characterized by the accumulation of proteins and protein fragments in the brain, progressive neuronal loss, inflammation, and the gradual and inevitable decline of memory and cognition. Decline of memory and cognition is coupled with binding of β amyloid peptides (Aβ) and their derived diffusible ligands (ADDL) to the nicotinic acetylcholine receptor (AChR). To prevent this binding and improve cognition, we are designing, synthesizing, and testing new drugs that are capable of disrupting the calamitous interactions of Aβ with AChR, dull it’s anesthesia like effect, and prevent neurodegeneration. For drug design, we use proprietary software based on normal mode dynamics developed in our laboratory. These software have shown promising results with 98% accuracy in predicting ligand binding sites and drug screening. For chemical synthesis, we use our highly experienced chemistry laboratory. In the past, we synthesized complex molecules and drugs with high yields. Preliminary results of our drugs are promising in that they bind AChR without interfering with acetylcholine binding. These Aβ like drugs open a new window of opportunity for the treatment and prevention of Alzheimer's disease. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencescomputer and information sciencessoftwaremedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Call for proposal FP7-PEOPLE-2012-CIG See other projects for this call Funding Scheme MC-CIG - Support for training and career development of researcher (CIG) Coordinator BAR ILAN UNIVERSITY Address Bar ilan university campus 52900 Ramat gan Israel See on map Activity type Higher or Secondary Education Establishments Administrative Contact Estelle Waise (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
