Objective Enteric and respiratory diseases remain a major cause of mortality during neonate life and childhood within developing countries. This proposal will focus on bacteria that enter through or colonize enteric and respiratory mucosa and that are of main importance for public health in Latin America, i.e. Streptococcus pneumoniae, Salmonella enterica serovar Enteritidis, and Bordetella pertussis.The selected bacterial pathogens are associated with important rates of morbidity and mortality in South America, especially in young children and low socio-economic status individuals. Moreover, the strains and serotypes that cause infections are unique to the developing countries in this area and consequently, basic research and development of therapies and vaccines tailored to these local strains have been deserted by the European and North American scientific community.The objectives of our concerted efforts are to gain in our understanding of the host-pathogen interaction in order to define novel strategies of interventions. For this purpose, we will study on the one hand, virulence mechanisms of bacterial pathogens and on the other hand, the early innate immune response of the host. This will allow to identify molecules from these bacteria that(1) can be targeted by novel antibiotics (strain-specific virulence factors) and(2) activate specifically protective mucosal innate immunity (conserved pathogen-associated molecular patterns) in order to block the infections at the port of entry of bacteria. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronavirusesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) INCO - Specific measures in support of international co-operation INCO-2003-A1.3 b - Knowledge and technologies to improve control of neglected communicable diseases Call for proposal FP6-2004-INCO-DEV-3 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Address Rue de tolbiac 101 Paris France See on map Links Website Opens in new window EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSIDAD NACIONAL DE LA PLATA Argentina EU contribution € 0,00 Address Calle 47 y 115 La plata See on map Links Website Opens in new window IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 0,00 Address South kensington campus London See on map Links Website Opens in new window EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH Switzerland EU contribution € 0,00 Address Raemistrasse 101 Zurich See on map Links Website Opens in new window UNIVERSIDAD DE LA REPUBLICA ORIENTAL DEL URUGUAY Uruguay EU contribution € 0,00 Address Avda. gral. flores 2125 Montevideo See on map Links Website Opens in new window PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE Chile EU contribution € 0,00 Address Alameda 340 Santiago See on map Links Website Opens in new window INSTITUTO BIOLOGICO ARGENTINO SAIC Argentina EU contribution € 0,00 Address Jose e. uriburu 153 Ciudad autonoma de buenos aires See on map Links Website Opens in new window
