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Novel therapeutic and prophylactic strategies to control mucosal infections by South American bacterial strains

Objective

Enteric and respiratory diseases remain a major cause of mortality during neonate life and childhood within developing countries. This proposal will focus on bacteria that enter through or colonize enteric and respiratory mucosa and that are of main importance for public health in Latin America, i.e. Streptococcus pneumoniae, Salmonella enterica serovar Enteritidis, and Bordetella pertussis.

The selected bacterial pathogens are associated with important rates of morbidity and mortality in South America, especially in young children and low socio-economic status individuals. Moreover, the strains and serotypes that cause infections are unique to the developing countries in this area and consequently, basic research and development of therapies and vaccines tailored to these local strains have been deserted by the European and North American scientific community.

The objectives of our concerted efforts are to gain in our understanding of the host-pathogen interaction in order to define novel strategies of interventions. For this purpose, we will study on the one hand, virulence mechanisms of bacterial pathogens and on the other hand, the early innate immune response of the host. This will allow to identify molecules from these bacteria that
(1) can be targeted by novel antibiotics (strain-specific virulence factors) and
(2) activate specifically protective mucosal innate immunity (conserved pathogen-associated molecular patterns) in order to block the infections at the port of entry of bacteria.

Call for proposal

FP6-2004-INCO-DEV-3
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
Paris
France

Participants (6)

UNIVERSIDAD NACIONAL DE LA PLATA
Argentina
Address
Calle 47 Y 115
La Plata
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Address
South Kensington Campus
London
EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH
Switzerland
Address
Raemistrasse 101
Zurich
UNIVERSIDAD DE LA REPUBLICA ORIENTAL DEL URUGUAY
Uruguay
Address
Avda. Gral. Flores 2125
Montevideo
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Chile
Address
Alameda 340
Santiago
INSTITUTO BIOLOGICO ARGENTINO SAIC
Argentina
Address
Jose E. Uriburu 153
Ciudad Autonoma De Buenos Aires