Objetivo Drug delivery systems are a matter of intensive scientific investigation and technological developments. They are necessary since many active pharmaceutical ingredients to be employed in therapy, diagnostics or vaccination cause serious side effects when distributed non-specifically. Without a drug delivery system, the active pharmaceutical ingredients may accumulate in healthy and sensitive tissue, provoke adverse immune reactions, have poor solubility, low bioavailability and inefficient targeting.To meet these challenges, the key objectives of the proposed project are the development and testing of an innovative production technology for nanocapsules as a drug delivery system using centrifugation, colloidal and fluid mechanical techniques. These novel nanocapsules should be especially suited for proteins and other sensitive biomolecules which are vulnerable to degradation by existing encapsulation technologies. An immune protection consisting of a suitable polymer cover of the nanocapsules has to be developed to enable long circulation in human blood without provoking innate immune reactions by the complement, the coagulation and the phagocytic systems. Other than established polymer protection systems, the novel polymer protection should not be immunogenic to avoid accelerated blood clearance upon repeated administration. The nanocapsules have to prove to be sufficiently stable in human blood ex vivo. In vitro and in vivo tests in cancer models will be performed to compare drug efficiency, immune reactions and organ distribution of encapsulated and non encapsulated active pharmaceutical ingredients. Multidisciplinary research and innovation for nanomedicine is aimed for by collaboration in an intersectoral research team comprising mechanical and process engineering, pharmaceutical technology, immunology and cancer research. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencespolymer sciencesmedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesclinical medicineoncology Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2012-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Convocatoria de propuestas FP7-PEOPLE-2012-IAPP Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinador ABNOBA GMBH Aportación de la UE € 481 842,40 Dirección HOHENZOLLERNSTRASSE 16 75177 PFORZHEIM Alemania Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Gero Leneweit (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITEIT UTRECHT Países Bajos Aportación de la UE € 464 451,69 Dirección HEIDELBERGLAAN 8 3584 CS Utrecht Ver en el mapa Región West-Nederland Utrecht Utrecht Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Martin De Geest (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UPPSALA UNIVERSITET Suecia Aportación de la UE € 272 463,21 Dirección VON KRAEMERS ALLE 4 751 05 Uppsala Ver en el mapa Región Östra Sverige Östra Mellansverige Uppsala län Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Pirkko Boox (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos KARLSRUHER INSTITUT FUER TECHNOLOGIE Alemania Aportación de la UE € 273 787,80 Dirección KAISERSTRASSE 12 76131 Karlsruhe Ver en el mapa Región Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Nadja Hafendörfer (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos