Final Report Summary - XENO-AUTOANTIBODIES (Immune Recognition of Xeno-Glycans)
This project aimed at designing novel therapetics based on xeno-autoantibodies. During the grant period we were able to affinity-purify such antibodeis for further characterization and in addition genered novel glyco-nanoparticles as immunogens to facilitate cancer-associated immune response to xeno-autoglycans in a relevant mouse model. Further studies will further characterize ther therapeutic potential in our mouse cancer model.