Objective The development of new methodologies which allow for the direct synthesis of highly complex molecular entities bearing vicinal all carbon quaternary stereocentres remains a most important goal for modern synthetic chemists.The aim of this proposal is to develop cutting-edge methodology for congested molecule synthesis and apply it to the total synthesis of the core of a highly complex natural product.Phase 1 of the project will involve the development of three related methodologies which will allow for the efficient synthesis of a wide range of highly complex tricyclic molecules bearing multiple stereocentres including vicinal all carbon quaternary stereocentres from simple achiral starting materials.In Phase 2 of the project the developed methodologies will be used to synthesise the complex tetracyclic core of a highly complex biologically active terpenoid natural product. The tetracyclic core will be further functionalised using state-of-the-art synthetic transformations. Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Call for proposal FP7-PEOPLE-2012-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD EU contribution € 221 606,40 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford United Kingdom See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Gill Wells (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
