Ziel
The development of new methodologies which allow for the direct synthesis of highly complex molecular entities bearing vicinal all carbon quaternary stereocentres remains a most important goal for modern synthetic chemists.
The aim of this proposal is to develop cutting-edge methodology for congested molecule synthesis and apply it to the total synthesis of the core of a highly complex natural product.
Phase 1 of the project will involve the development of three related methodologies which will allow for the efficient synthesis of a wide range of highly complex tricyclic molecules bearing multiple stereocentres including vicinal all carbon quaternary stereocentres from simple achiral starting materials.
In Phase 2 of the project the developed methodologies will be used to synthesise the complex tetracyclic core of a highly complex biologically active terpenoid natural product. The tetracyclic core will be further functionalised using state-of-the-art synthetic transformations.
Thema/Themen
Aufforderung zur Vorschlagseinreichung
FP7-PEOPLE-2012-IEF
Andere Projekte für diesen Aufruf anzeigen
Finanzierungsplan
MC-IEF - Intra-European Fellowships (IEF)Koordinator
OX1 2JD Oxford
Vereinigtes Königreich