Nicotinic acetylcholine receptors in human adrenal chromaffin cells

Project Information

NRHACC

Grant agreement ID: 329966

Project closed

Start date 29 July 2013

End date 28 July 2015

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 166 336,20

EU contribution € 166 336,20

Coordinated by

UNIVERSIDAD AUTONOMA DE MADRID
Spain

Objective

Nicotinic acetylcholine receptors (nAChRs) containing the alpha6 subunit have been implicated in neurological and psychiatric conditions including Parkinson’s and nicotinic dependence. Despite their potential therapeutic importance, little is known about the biophysical properties of these receptors in part because of their restricted tissue distribution and poor expression in heterologous systems. Nevertheless, a recent report by Dr. Albillos’ laboratory demonstrated that the alpha6beta4 subtype is the main nAChR expressed in human adrenal chromaffin cells. This seminal report constitutes the only functional demonstration of native human alpha6beta4 nAChRs and represents a timely opportunity to gain valuable insights into its biophysical properties and to further our understanding of this receptors involvement in the stimulus-secretion response of chromaffin cells. This proposal intends to characterize the biophysical properties of native human alpha6beta4 nAChRs, their interaction with mitochondria via calcium, and their functional regulation by reactive oxygen species (ROS) produced by mitochondria under pathological conditions. The specific aims of this proposal are: 1) to characterize the alpha6-containing nAChR subtype(s) present in human adrenal chromaffin cells and to investigate the regulation of their expression by nicotine; 2) to study the functional interaction between alpha6beta4 nAChRs and mitochondria; 3) the regulation of this nAChR subtype by mitochondrial ROS.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• natural sciences › chemical sciences › inorganic chemistry › alkaline earth metals
• medical and health sciences › basic medicine › neurology › parkinson

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2012-IIF - Marie Curie Action: "International Incoming Fellowships"

Call for proposal

FP7-PEOPLE-2012-IIF
See other projects for this call

Funding Scheme

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

UNIVERSIDAD AUTONOMA DE MADRID

• EU contribution: € 166 336,20
• Address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO ; 28049 Madrid ; Spain
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data